Ask your doctor or pharmacist about using this product safely. Promethazine is a phenothiazine that works like an antihistamine. Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats. Avoid drinking alcohol. Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Why You Should Rethink That Drink Before Dinner, New Clues Why Mosquitoes Find You Irresistible, Popular Heartburn Meds Can Have Health Risks. Promethazine-DM syrup should only be prescribed to relieve the symptoms of upper respiratory infections. Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as 10H-Phenothiazine-10-ethanamine, N,N, α-trimethyl-monohydrochloride. There are no animal or human data concerning the carcinogenicity, mutagenicity, or impairment of fertility with these drugs.
See the Ask the Pharmacist event schedule. Dextromethorphan: Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of monoamine oxidase (MAO) inhibitors and products containing dextromethorphan. Administration of dextromethorphan may be accompanied by histamine release and should be used with caution in atopic children. Tell your doctor right away if you get sunburned or have skin blisters/redness. If you are very sleepy or have difficulty waking up after using this medication, stop taking this medication and talk to your doctor or pharmacist right away. Do not use Promethazine with DM if you have asthma or other lung disease. Use sunscreen and wear protective clothing when outdoors.
To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If you do not have a dose-measuring device, ask your pharmacist for one. Special caution should be taken in children with a family history of sudden infant death syndrome (SIDS), those who have a severe loss of fluid (dehydration), and those who are hard to wake up from sleep. It hurt to cough. Thus, concomitant administration of promethazine with dextromethorphan and MAO inhibitors should be avoided (see CONTRAINDICATIONS). Animal reproduction studies have not been conducted with the drug combination–promethazine and dextromethorphan.
Do not start using a new medication without telling your doctor.
Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has been used in association with other known marrow toxic agents. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. These could be early signs of dangerous side effects. CNS Depression: Promethazine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Do not share this medication with others. Questions about medications? The treatment of overdosage with promethazine and dextromethorphan is essentially symptomatic and supportive. Read the label of any other medicine you are using to see if it contains dextromethorphan. Are you planning to see a doctor about switching your medication? It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. In humans, (+)-3-hydroxy-N-methyl-morphinan, (+)-3-hydroxymorphinan, and traces of unmetabolized drug were found in urine after oral administration. found this review helpful.
Keep all medications away from children and pets. A paradoxical reaction has been reported in children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares. Avoid using other drugs that make you sleepy (such as cold medicine, sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). THE USE OF PROMETHAZINE PRODUCTS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE'S SYNDROME OR OTHER HEPATIC DISEASES. Pregnancy Tests: Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Search by name or medical condition. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). More about Promethazine DM (dextromethorphan / promethazine) Side Effects; During Pregnancy; Dosage Information; Drug Interactions; Drug class: upper respiratory combinations; FDA Alerts (1) Consumer resources. Dextromethorphan may produce central excitement and mental confusion. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). If you are using any of these drugs, you may not be able to use Promethazine with DM, or you may need dosage adjustments or special tests during treatment. It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Symptoms of overdose may include: severe drowsiness, inability to wake up, slow/shallow breathing, slow heartbeat, hallucinations, seizures. Inability to sleep due to cough.
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